Equatoria Biosciences
The Science

One molecule. Many frontiers.

Tabernanthe iboga stores its pharmacological power in its root bark, where a family of indole alkaloids — most notably ibogaine and its active metabolite noribogaine — accumulates over years of slow growth.

Ibogaine molecular structure visualization
C₂₀H₂₆N₂O · 310.43 g/mol

Ibogaine

A naturally occurring psychoactive indole alkaloid concentrated in the root bark of Tabernanthe iboga. Unlike conventional pharmaceuticals, ibogaine appears to act as a reset switch on the brain's reward and habit circuits.

Receptor activity
NMDA antagonist · κ-opioid agonist · σ2 modulator
Half-life
Rapidly metabolized to noribogaine, which persists for days
Mechanism
Hypothesized to upregulate GDNF and induce synaptic plasticity
Global research landscape

Breakthrough studies, on every continent.

USA2024
Stanford University

Magnesium-paired ibogaine for TBI in special-operations veterans

Brazil & MexicoOngoing
Multidisciplinary Trials

Ibogaine-assisted detoxification for opioid-use disorder

USA / EU2023–2025
DemeRx / Atai

Noribogaine derivative development — Phase I/II

New Zealand2018–2024
University of Auckland

Long-term abstinence outcomes following single-dose treatment

UKOngoing
Imperial College London

Neuroplasticity mechanisms of indole alkaloids

UKOngoing
Beckley Foundation

Policy & clinical framework for psychedelic-assisted therapy

Examples drawn from the public research landscape; Equatoria Biosciences is not affiliated with the institutions listed unless otherwise stated.

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